Intergenic interactions and genetic polymorphism in increasing the probability of alcoholic dependence

The results of molecular genetic analysis 13 polymorphic variants genes, according to the data genome-wide association studies (GWAS) associated with development addictive states, in group persons alcohol dependence (n = 142) and comparison 211) are presented. main genotyping method is polymerase chain reaction (PCR) followed by high resolution melting (HRM) clustering profiles; validated using restriction fragment length polymorphism (PCR-RFLP) method. As a result, single nucleotide polymorphisms an increased likelihood genotype GG (rs7085104, AS3MT); (rs7590720, PECR); allele C (rs11191580, NT5C2); T (rs17504622); A (rs73229090, EPHX2); (rs1109501, MUC7 ).